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Chemical Name:(6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahyd
ro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methan
ol
Biological Activity:
A highly potent cannabinoid receptor
agonist (Ki values are 0.061 and 0.52 nM at cloned human CB1
and CB2 receptors respectively). Induces spatial memory deficits and
suppresses hippocampal firing rates in rats.
Mechoulamet al (1988) Enantiomeric cannabinoids: stereospecificity
of psychotropic activity. Experientia 44 762. Howlettet
al (1990) Stereochemical effects of 11-OH-D8-tetrahydrocannabinol-dimethylheptyl
to inhibit adenylate cyclase and bind to the cannabinoid receptor.Neuropharmacology 29 161. Robinson
et al (2007) The synthetic cannabinoid HU210 reduces spatial memory
deficits and suppresses hippocampal firing rates in rats. Br.J.Pharmacol. 151
688.
Highly selective CB2 receptor agonist; Ki values are 0.037 and 363 nM for CB2 and CB1 receptors respectively. Increases P-ERK1/2 expression in HL-60 cells in vitro.
