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Category:
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Enzymes PolymerasesPoly(ADP-ribose) Polymerase
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Cat.No.
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Product Name
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2192 |
4-HQN
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Price and Availability
Click here for full price details of
4-HQN
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Chemical Name:
4-(1H)-Quinazolinone |
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Biological Activity:
Inhibitor of poly(ADP-ribose)
polymerase (PARP) (IC50 = 9.5 μM);
displays mixed inhibition with respect to NAD+. Protective against
ischaemia-reperfusion induced ROS production, and subsequent mitochondrial and
cell damage in rat heart. Anti-inflammatory in LPS-induced endotoxic mice in
vivo; decreases NF-κB and AP-1 activation.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Banasik et al (1992) Specific inhibitors of poly(ADP-ribose)
synthetase and mono(ADP-ribosyl)transferase. J.Biol.Chem. 267
1569. Halmosi et al (2001) Effect of poly(ADP-ribose) polymerase
inhibitors on the ischemia-reperfusion-induced oxidative cell damage and
mitochondrial metabolism in Langendorff heart perfusion system. Mol.Pharmacol. 59
1497. Veres et al (2004) Regulation of kinase cascades and
transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor,
4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice.
J.Pharmacol.Exp.Ther. 310 247.
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View related products by Pharmacological Action
or by Research Area
Keywords: 4-HQN, Polymerases, PARP Inhibitor, 4HQN, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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