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Category: EnzymesarrowKinasesarrowRho-kinases
Cat.No. Product Name
2415 HA 1100 hydrochloride
Alternative name(s): Hydroxyfasudil
Price and Availability

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HA 1100
Chemical Name: 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydr o-1H-1,4-diazepine

Biological Activity:

Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.

Technical Data:

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M.Wt: 343.83
Formula: C14H17N3O3S.HCl
Storage: Store at -20°C
Solubility: Soluble to 20 mM in Water
Purity: >99%
CAS No: [105628-72-6]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Arai et al (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487. Shimokawa et al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 43 1029. Utsunomiya et al (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 134 1724.
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    Keywords: HA 1100, Kinases, Cell-permeable, Selective Rho-kinase Inhibitor, Hydroxyfasudil, HA1100, Tocris Bioscience
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