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Category: Ion ChannelsarrowLigand-gated Ion Channelsarrow5-HT3 ReceptorsarrowAntagonists
Cat.No. Product Name
2903 Granisetron hydrochloride
Alternative name(s): BRL 43694
Price and Availability

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Granisetron
Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3- yl]-1H-indazole-3-carboxamide hydrochloride

Biological Activity:

5-HT3 receptor antagonist that possesses potent antiemetic activity.

Technical Data:

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M.Wt: 348.87
Formula: C18H24N4O.HCl
Storage: Desiccate at +4°C
Solubility: Soluble to 100 mM in Water and to 10 mM in DMSO
Purity: >99%
CAS No: [107007-99-8]

Resources:

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    • Certificate of Analysis / MSDS:

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    Product/Material Safety Data Sheet: View current batch

    References:

    Sanger and Nelson (1989) Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur.J.Pharmacol. 159 113. Plosker and Goa (1991) Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic. Drugs 42 805. Martin et al (1998) Anti-emetic effect of Ondansetron and Granisetron after exposure to mixed neutron and gamma irradiation. Rad.Res. 149 631.
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    Keywords: Granisetron, Ligand-gated Ion Channels, 5-HT3 Antagonist, BRL 43694, Tocris Bioscience
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