|
Category:
|
Cellular Processes and Components Signal TransductionCytokine and NFkB SignallingNFkB/IkB
|
|
Cat.No.
|
Product Name
|
|
2637 |
Gliotoxin
|
| Alternative name(s): |
Aspergillin |
|
|
Price and Availability
Click here for full price details of
Gliotoxin
|
|
Chemical Name:
(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydro
xymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]in
dole-1,4-dione |
|
|
Biological Activity:
Immunosuppressive
agent; blocks phagocytosis, cytokine production and proliferation of T and B
cells. Non-competitively inhibits chymotrypsin-like activity of 20S proteasome;
prevents degradation of IκBa, an endogenous blocker of NF-κB. Also inhibits farnesyltransferase
and geranylgeranyltransferase I (IC50 values are 80 and 17 μM respectively) and displays
antitumour activity against breast cancer in vivo.
|
Technical Data:
|
|
|
Resources:
|
|
Certificate of Analysis / MSDS:
|
References:
Waring
and Beaver (1996)
Gliotoxin and related epipolythiodioxopiperazines. Gen.Pharmacol. 27
1311. Fitzpatrick et al (2000) In vitro and in vivo effects of
gliotoxin, a fungal metabolite: efficacy against dextran sodium sulfate-induced
colitis in rats. Dig.Dis.Sci. 45 2327. Vigushin et al
(2004) Gliotoxin is a dual inhibitor of farnesyltransferase and
geranylgeranyltransferase I with antitumour activity against breast cancer in
vivo. Med.Oncol. 21 21.
|
|
View related products by Pharmacological Action
or by Research Area
Keywords: Gliotoxin, Signal Transduction, Immunosuppressant; Inhibits NF-kB & Cytokine Production, Aspergillin, Tocris Bioscience
|
|
Literature in this Area Cancer Research Guide | Our unique collection of more than 300 products related to cancer research, including the very latest exclusive research tools. | | Request Copy / View PDF |
Product Feature
Proteasome and NF-κB
Key proteasome inhibitors now available from Tocris include:
1748
MG 132
Proteasome & calpain inhibitor. Inhibits NF-κB activation
2637
Gliotoxin
Immunosuppressant; inhibits NF-κB & cytokine production
|
