Glimepiride | Potassium Channels | K+ Channel Opener (KATP) | Amaryl | Glimperide

Category:

Ion Channels

Potassium Channels

ATP-Activated Potassium Channels

Cat.No.

Product Name

2396

Glimepiride

Alternative name(s):	Amaryl
	Glimperide

Price and Availability

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Glimepiride

Chemical Name: 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methy lcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl] -2-oxo-1H-pyrrole-1-carboxamide

Biological Activity:

Potent K_ATP channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac K_ATP channels with an IC₅₀ of 6.8 nM.

Technical Data:

M.Wt:	490.62
Formula:	C₂₄H₃₄N₄O₅S
Storage:	Store at +4°C
Solubility:	Soluble to 25 mM in DMSO
Purity:	>98%
CAS No:	[93479-97-1]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Lawrence et al (2002) Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sacrolemmal K_ATP channels. Br.J.Pharmacol. 136 746.

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Keywords: Glimepiride, Potassium Channels, K+ Channel Opener (KATP), Amaryl, Glimperide, Tocris Bioscience

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