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Glibenclamide
Chemical Name:5-Chloro-N-[2-[4-[[[(Cylcohexylamino)carbonyl]amino]sul
phonyl]phenyl]ethyl]-2-methoxybenzamide
Biological Activity:
ATP-dependent K+ channel
(KATP) and CFTR Cl- channel blocker. Inhibits KATP
currents in the pancreas, causing an increase in intracellular Ca2+
and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC50
of 20 μM.
“I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..”
