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Category:
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7TM Receptors 5-HT Receptors5-HT4 ReceptorsAntagonists
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Cat.No.
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Product Name
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1658 |
GR 125487 sulfamate
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Price and Availability
Click here for full price details of
GR 125487
Other Information:
Sold for
research purposes under agreement from GlaxoSmithKline
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Chemical Name:
5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-
4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate |
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Biological Activity:
Potent
and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for
porcine 5-HT4). Centrally active following systemic administration
in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Schiavi et al (1994) Identification
of serotonin 5-HT4 recognition sites in the porcine caudate nucleus
by radioligand binding. Neuropharmacology 33 543. Galeotti et
al (1998) Role of 5-HT4 receptors in the mouse passive avoidance
test. J.Pharmacol.Exp.Ther. 286 1115. Horikoshi et al (2001)
Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the
emesis induced by high-dose cisplatin in Suncus murinus. Jpn.J.Pharmacol. 85
70.
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or by Research Area
Keywords: GR 125487, 5-HT Receptors, Potent, Selective 5-HT4 Antagonist. Active In Vivo, GR125487, Tocris Bioscience
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