Tocris Bioscience
 Welcome to Tocris

| Advanced Search
Home Products Technical Support Customer Support Literature Custom Synthesis
Category: EnzymesarrowKinasesarrowProtein Kinase C
Cat.No. Product Name
0741 GF 109203X  
Alternative name(s): Gö 6850
Bisindolylmaleimide I
Price and Availability

Click here for full price details of
GF 109203X
Chemical Name: 2-[1-(3-Dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl) maleimide

Biological Activity:

Very potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, e, and z isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM). Anti-inflammatory in vivo.

Technical Data:

 Click here for more information on batch specific data
M.Wt: 412.49
Formula: C25H24N4O2
Storage: Store at RT
Solubility: Soluble to 25 mM in DMSO
Purity: >98%
CAS No: [133052-90-1]

Resources:

    		•

    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    For specific/earlier batch please select:  
    Product/Material Safety Data Sheet: View current batch
    For specific/earlier batch please select:  

    References:

    Toullec et al (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J.Biol.Chem. 266 15771. Martiny-Baron et al (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J.Biol.Chem. 268 9194. Jacobson et al (1995) Anti-inflammatory properties of Go 6850: a selective inhibitor of protein kinase C. J.Pharmacol.Exp.Ther. 275 995. Coultrap et al (1999) Competitive antagonism of the mouse 5-hydroxytryptamine3 receptor by bisindolylmaleimide I, a ''selective'' protein kinase C inhibitor. J.Pharmacol.Exp.Ther. 290 76.
    View related products by Pharmacological Action or by Research Area

    Keywords: GF 109203X, Kinases, Protein Kinase C Inhibitor, Gö 6850, Bisindolylmaleimide I, GF109203X, Tocris Bioscience
    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
    Product Feature
    Kinase Inhibitors
    Key kinase Inhibitors available from Tocris include:
    2718   LY 364947
    Selective inhibitor of TGF-β RI
    2693   PHA 665752
    Potent & selective cMET inhibitor
    2605   PD 198306
    Potent & selective inhibitor of MEK1/2
    2539   IKK 16
    Selective inhibitor of IKK
    View Product Feature
    New Products in this Area

     2930PI 103 hydrochloride
     Inhibitor of PI 3-kinase, mTOR and DNA-PK
     3028Rp-8-Br-PET-cGMPS
     Protein kinase G inhibitor
     2992PKC 412
     Protein kinase C inhibitor
     2977GW 843682X
     Selective inhibitor of PLK1 and PLK3
     2828NU 7026
     Selective DNA-dependent protein kinase inhibitor
     2938SD 169
     Selective, orally active p38α inhibitor
     2910H 89 dihydrochloride
     Protein kinase A inhibitor
     2864Metformin hydrochloride
     Activator of LKB1/AMPK; antidiabetic agent
     2877MNS
     Selective inhibitor of Src and Syk
     2794PP 3
     Negative control for PP 2 (Cat. No. 1407)
     2755DCA
     Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor
     1571Cucurbitacin I
     Selective inhibitor of STAT3/JAK2 signalling
     2731CGP 57380
     Selective inhibitor of Mnk1
     1626Calphostin C
     Potent, selective and photo-dependent PKC inhibitor
     2253Go 6976
     Potent protein kinase C inhibitor; selective for α and β isozymes
     2560SB 218078
     Inhibitor of checkpoint kinase 1 (Chk1)
     2539IKK 16
     Selective inhibitor of IKK
     2605PD 198306
     Selective inhibitor of MEK1/2
     2651AEG 3482
     Inhibitor of JNK signalling
     2639CGK 733
     Selective inhibitor of ATR and ATM kinases
     2609Ryuvidine
     Cyclin-dependent kinase 4 (cdk4) inhibitor
     2694PD 407824
     Selective inhibitor of Chk1 and Wee1
     1587Ro 32-0432 hydrochloride
     Potent, orally active PKC inhibitor
     2285Go 6983
     Broad spectrum PKC inhibitor
     2485Glycyl-H 1152 dihydrochloride
     More selective analogue of Cat. No. 2414
     2559TPCA-1
     Potent, selective inhibitor of IKK-2
     2611IMD 0354
     Inhibitor of IKK-2
     2657JX 401
     Potent, reversible p38α inhibitor
     2414H 1152 dihydrochloride
     Selective rho-kinase (ROCK) inhibitor
     2287K-252c
     Protein kinase C inhibitor
     255810-DEBC hydrochloride
     Selective Akt/PKB inhibitor
     2549ZIP
     Cell-permeable inhibitor of atypical PKC isozyme PKMz
     2383Bryostatin 1
     Protein kinase C activator
     2357Anti-Cdk2
     Antibody recognising Cdk2
     2367Anti-PKC
     Antibody recognising PKC
     2356Anti-Cdk1 and Cdk2
     Antibody recognising Cdk1 and Cdk2
     2358Anti-c-Jun
     Antibody recognising c-Jun
     2243MEK Inhibitor TocrisetTM
     Selection of 3 MEK inhibitors (Cat. Nos. 1213, 1969 and 1144)
     2244p38 MAPK Inhibitor TocrisetTM
     Selection of 3 p38 MAPK inhibitors (Cat. Nos. 1264, 1202 and 1962)
    Sign-up for new product e-alerts
    Log In / Register

    User ID
    Password
    If you are not registered with us Create Account
    Home | About | Contact | Environment | Distributors | Glossary | Ordering | Security | Privacy | Terms & Conditions | Services | Site Map