GBR 12935 Dihydrochloride | Neurotransmitter Transporters | Selective Dopamine Uptake Inhibitor | GBR12935 Dihydrochloride

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Cat.No.	Product Name
0514	GBR 12935 dihydrochloride

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GBR 12935 dihydrochloride

Chemical Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazine dihydrochloride

Biological Activity:

Potent and selective inhibitor of dopamine uptake (K_D = 5.5 nM in rat striatal membranes).

Technical Data:

M.Wt:	487.51
Formula:	C₂₈H₃₄N₂O.2HCl
Storage:	Desiccate at -20°C
Solubility:	Soluble in Water
CAS No:	[76778-22-8]

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References:

Andersen et al (1987) Biochemical and pharmacological characterization of [³H]GBR 12935 binding in vitro to rat striatal membranes: labelling of the dopamine uptake complex. J.Neurochem. 48 1887. Reith et al (1992) Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. Eur.J.Pharmacol.Mol.Pharmacol.Sect. 227 417. Reith et al (1994) GBR 12909 and 12935 block dopamine uptake into brain synaptic vesicles as well as nerve endings. Eur.J.Pharmacol. 253 175.

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Keywords: GBR 12935 Dihydrochloride, Neurotransmitter Transporters, Selective Dopamine Uptake Inhibitor , GBR12935 Dihydrochloride, Tocris Bioscience

Literature in this Area

Scientific Reviews

Dopamine Receptors
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Product Feature

Uptake Inhibitors

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