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Category:
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Nuclear Receptors Glucocorticoid Receptor
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Cat.No.
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Product Name
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2007 |
Fluticasone propionate
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Price and Availability
Click here for full price details of
Fluticasone propionate
Other Information:
Sold for
research purposes under agreement from GlaxoSmithKline
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Chemical Name:
(6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-ox
o-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic
acid fluoromethyl ester |
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Biological Activity:
High
affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM).
Potently stimulates glucocorticoid receptor-mediated transactivation of gene
expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM)
in vitro. Inhibits mast cell accumulation in nasal mucosa following topical
administration. Lipophilic, clinically-used anti-inflammatory agent with low
oral bioavailability.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Johnson
(1995) The
anti-inflammatory profile of fluticasone propionate. Allergy 50
11. Smith and Kreutner (1998) In vitro glucocorticoid receptor binding
and transcriptional activation by topically active glucocorticoids.
Arzneim.-Forsch. 48 956. Zhang et al (2000)
Enhancement of human eosinophil apoptosis by fluticasone propionate,
budesonide, and beclomethasone. Eur.J.Pharmacol. 406 325.
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Keywords: Fluticasone Propionate, Glucocorticoid Receptor, Selective High Affinity Glucocorticoid Agonist, Tocris Bioscience
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