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Fluoxetine hydrochloride
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Chemical Name:N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropyla
mine hydrochloride
Biological Activity:
Selective serotonin reuptake
inhibitor. Binds to the human 5-HT transporter with a Ki of 0.9
nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A,
H1, α1, α2-adrenergic, and
muscarinic receptors. Antidepressant.
Benfieldet al (1996) Fluoxetine. A review of its pharmacodynamic
properties, and therapeutic efficacy in depressive illness. Drugs 32
481. Becket al (1997) Fluoxetine selectively alters
5-hydroxytryptamine1A and γ-aminobutyric acidB
receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal
pyramidal cells. J.Pharmacol.Exp.Ther. 281 115. Owenset
al (1997) Neurotransmitter receptor and transporter binding profile of
antidepressants and their metabolites. J.Pharmacol.Exp.Ther. 283 1305.
