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Category:
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Ion Channels Calcium ChannelsVoltage-gated Calcium Channels
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Cat.No.
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Product Name
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2960 |
Felodipine
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Price and Availability
Click here for full price details of
Felodipine
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Chemical Name:
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyr
idinedicarboxylic acid ethyl methyl ester |
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Biological Activity:
L-type Ca2+ channel
blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high
vascular selectivity; lowers arterial blood pressure without altering cardiac
contractility. Antihypertensive.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ljung (1990)
Vascular selectivity of felodipine: experimental pharmacology.
J.Cardiovasc.Pharmacol. 15 S11. Furukawa et al
(1999) Selectivities of dihydropyridine derivatives in blocking Ca2+
channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 291
464. Furukawa et al (2005) Differential blocking action of
dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel
(α1G)
expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 45
241.
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View related products by Pharmacological Action
or by Research Area
Keywords: Felodipine, Calcium Channels, L-type Ca2+ Channel Blocker, Tocris Bioscience
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Literature in this Area Scientific Reviews
Mechanisms for Manipulating Intracellular Calcium Buffering Download PDF Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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