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Category: Nuclear ReceptorsarrowMineralocorticoid Receptor
Cat.No. Product Name
2397 Eplerenone
Alternative name(s): Inspra
Epoxymexrenone
Price and Availability

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Eplerenone
Chemical Name: (7a,11a,17a)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7, 21-dicarboxylic acid g-lactone methyl ester

Biological Activity:

Selective mineralocorticoid (aldosterone) receptor antagonist (IC50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC50 > 10 μM). Orally active antihypertensive in vivo.

Technical Data:

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M.Wt: 414.5
Formula: C24H30O6
Storage: Store at RT
Solubility: Soluble to 10 mM in DMSO
Purity: >99%
CAS No: [107724-20-9]

Resources:

  • Certificate of Analysis / MSDS:

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    References:

    De Gasparo et al (1987) Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. J.Pharmacol.Exp.Ther. 240 650. McMahon (2001) Recent studies with eplerenone, a novel selective aldosterone receptor antagonist. Curr.Opin.Pharmacol. 1 190.
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    Keywords: Eplerenone, Mineralocorticoid Receptor, Selective Mineralocorticoid Receptor Antagonist, Inspra, Epoxymexrenone, Tocris Bioscience

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