(±)-Epibatidine | Ligand-gated Ion Channels | Very Potent Nicotinic Agonist | Epibatidine

Category:

Cat.No.	Product Name
0684	(±)-Epibatidine

Price and Availability

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(±)-Epibatidine

Other Information:

Sold under licence from the NIH, US Patent 5,314,899

Chemical Name: (±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1.]he ptane

Biological Activity:

Very potent nicotinic agonist (K_i values are 0.02 and 233 nM for α4β2 and α7 nicotinic receptors respectively). Analgesic.

Technical Data:

M.Wt:	208.69
Formula:	C₁₁H₁₃ClN₂
Storage:	Desiccate at +4°C
Solubility:	Soluble to 5 mM in Water and to 100 mM in Ethanol
CAS No:	[140111-52-0]

Resources:

Certificate of Analysis / MSDS:

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References:

Spande et al (1992) Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity. J.Am.Chem.Soc. 114 3475. Badio and Daly (1994) Epibatidine, a potent analgesic and nicotinic agonist. Mol.Pharmacol. 45 563. Gerzarich et al (1995) Comparative pharmacology of epibatidine; a potent agonist for neuronal nicotinic acetylcholine receptors. Mol.Pharmacol. 48 774. Marks et al (1998) Differential agonist inhibition identifies multiple epibatidine binidng sites in mouse brain. J.Pharmacol.Exp.Ther. 285 377. Sharples et al (2000) UB-165 implicates α4β2 nAChR in striatal dopamine release. J.Neurosci. 20 2783.

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Keywords: (±)-Epibatidine, Ligand-gated Ion Channels, Very Potent Nicotinic Agonist , Epibatidine, Tocris Bioscience

Literature in this Area

Scientific Reviews

Nicotinic ACh Receptors
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