[Leu5]-Enkephalin | Opioid Receptors | Endogenous Opioid Agonist Peptide | ICI 114740 | Dynorphin-(1-5) | YGGFL

Category:

7TM Receptors

Opioid Receptors

Miscellaneous Opioids

Cat.No.

Product Name

1889

[Leu⁵]-Enkephalin

Alternative name(s):	ICI 114740
	Dynorphin-(1-5)
	YGGFL

Price and Availability

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[Leu5]-Enkephalin

Biological Activity:

Endogenous opioid agonist peptide; inhibits electrically stimulated contractions in mouse vas deferens (IC₅₀ = 11.4 nM). Short-acting in vivo.

Technical Data:

M.Wt:	555.63
Formula:	C₂₈H₃₇N₅O₇
Storage:	Desiccate at -20°C
CAS No:	[58822-25-6]

Resources:

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References:

Meunier et al (1977) Binding of Leu⁵-enkephalin and Met⁵-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209. Law and Loh (1978) ³H-Leu⁵-enkephalin specific binding to synaptic membrane - comparison with ³H-dihydromorphine and ³H-naloxone. Res.Commun.Chem.Pathol.Pharmacol. 21 409. DiMaio et al (1991) Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. J.Med.Chem. 25 1432.

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Keywords: [Leu5]-Enkephalin, Opioid Receptors, Endogenous Opioid Agonist Peptide, ICI 114740, Dynorphin-(1-5), YGGFL, Tocris Bioscience

Literature in this Area

Scientific Reviews

Opioid Receptors
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