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Category:
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Cellular Processes and Components ApoptosisXIAP
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Cat.No.
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Product Name
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2156 |
Embelin
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Price and Availability
Click here for full price details of
Embelin
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Chemical Name:
2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
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Biological Activity:
Cell-permeable, non-peptide inhibitor of X-linked inhibitor of
apoptosis (XIAP) (IC50 = 4.1 μM in competition binding assay with Smac peptide); binds to
the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits
cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells
(IC50 4-6 μM), but has a weaker
effect on normal prostate cells (IC50 = 19-20 μM). Overcomes the protective effect of XIAP on apoptosis in
XIAP-transfected Jurkat cells. Anti-tumour, analgesic and anti-inflammatory in
vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Chitra et al (1994) Antitumor, anti-inflammatory and analgesic
property of embelin, a plant product. Chemotherapy 40 109. Nikolovska-Coleska
et al (2004) Discovery of embelin as a cell-permeable, small-molecular
weight inhibitor of XIAP through structure-based computational screening of a
traditional herbal medicine three-dimensional structure database. J.Med.Chem. 47
2430.
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or by Research Area
Keywords: Embelin, Apoptosis, Inhibitor Of X-linked Inhibitor Of Apoptosis (XIAP); Cell-permeable & Antitumour, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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