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Category: EnzymesarrowKinasesarrowCasein Kinase
Cat.No. Product Name
3058 Ellagic acid
Price and Availability

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ellagic acid
Chemical Name: 2,3,7,8-Tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzop yran-5,10-dione

Biological Activity:

Selective, ATP-competitive inhibitor of casein kinase 2 (CK2) (IC50 values are 40, 2900, 3500, 4300 and 9400 nM for CK2, Lyn, PKA, Syk  and FGR respectively). Exhibits antioxidant, antitumour and anticarcinogenic activity and also inhibits glutathione S-transferase.

Technical Data:

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M.Wt: 302.19
Formula: C14H6O8
Storage: Store at RT
Solubility: Soluble to 5 mM in Water and to 10 mM in Ethanol
Purity: >99%
CAS No: [476-66-4]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Cozza et al (2006) Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J.Med.Chem. 49 2363. Han et al (2006) Antioxidant and apoptosis-inducing activities of ellagic acid. Anticancer Res. 26 3601. Hayeshi et al (2007) The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin. Food Chem.Toxicol. 45 286.
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    Keywords: Ellagic Acid, Kinases, Selective Inhibitor Of CK2. Also Inhibits Glutathione S-transferase, Tocris Bioscience
    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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