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Category:
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Enzymes DeacetylasesHistone Deacetylase
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Cat.No.
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Product Name
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2780 |
EX 527
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Price and Availability
Click here for full price details of
EX 527
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Chemical Name:
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide |
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Biological Activity:
Selective inhibitor of SIRT1 that does not
inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members
(IC50 values are 98, 19600, 48700, > 100000 and > 100000 nM
for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively). Enhances p53
acetylation in response to DNA damaging agents.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Napper et al
(2005) Discovery of indoles as potent and selective inhibitors of the
deacetylase SIRT1. J.Med.Chem. 48 8045. Solomon et al
(2006) Inhibition of SIRT1 catalytic activity increases p53 acetylation but
does not alter cell survival following DNA damage. Mol.Cell.Biol. 26
28.
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or by Research Area
Keywords: EX 527, Deacetylases, Selective SIRT1 Inhibitor, EX527, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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