EMD 386088 | 5-HT Receptors | Potent 5-ht6 Agonist | EMD386088

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Cat.No.	Product Name
2382	EMD 386088 hydrochloride

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EMD 386088

Chemical Name: 5-Chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H -indole hydrochloride

Biological Activity:

Potent 5-ht₆ receptor agonist (EC₅₀= 1.0 nM) that displays selectivity over other 5-HT receptors (IC₅₀ values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 for 5-HT₆, 5-HT_1D, 5-HT_1B, 5-HT_2A, 5-HT_2C, 5-HT₄, 5-HT_1A and 5-HT₇ receptors respectively). Shows moderate affinity at 5-HT₃receptors (IC₅₀ = 34 nM).

Technical Data:

M.Wt:	283.2
Formula:	_{C14H15N2Cl.HCl}
Storage:	Desiccate at RT
Solubility:	Soluble to 25 mM in Water and to 100 mM in DMSO
Purity:	>99%
CAS No:	[54635-62-0]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Mattsson et al (2005) 2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT₆ receptor agonists. Bioorg.Med.Chem.Lett. 15 4230.

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Keywords: EMD 386088, 5-HT Receptors, Potent 5-ht6 Agonist, EMD386088, Tocris Bioscience

Literature in this Area

Scientific Reviews

5-HT Receptors & their Ligands
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