Domperidone | Dopamine Receptors | Peripheral D2-like Antagonist | R 33812

Category:

7TM Receptors

Dopamine Receptors

D2-like Receptors

Antagonists

Cat.No.

Product Name

2536

Domperidone

Alternative name(s):

R 33812

Domperidone C22H24ClN5O2 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

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Domperidone

Chemical Name: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-y l)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2- one

Biological Activity:

Peripheral dopamine D₂-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and anti-emetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED₅₀ values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).

Technical Data:

M.Wt:	425.92
Formula:	C₂₂H₂₄ClN₅O₂
Storage:	Store at RT
Solubility:	Soluble to 5 mM in 1eq. HCl and to 100 mM in DMSO
Purity:	>99%
CAS No:	[57808-66-9]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Neimegeers et al (1980) The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int. Pharmacodyn.Ther. 244 130. Prakash and Wagstaff (1998) Domperidone. A review of its use in diabetic gastropathy. Drugs 56 429. Osinski et al (2005) Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 81 211.

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Keywords: Domperidone, Dopamine Receptors, Peripheral D2-like Antagonist, R 33812, Tocris Bioscience

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Dopamine Receptors
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