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Category:
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Cellular Processes and Components Apoptosis14-3-3
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Biological Activity:
Dimeric
version of R18 peptide (Cat. No. 2144) that binds to 14-3-3 proteins with high
affinity. Competitively inhibits 14-3-3-ligand interactions; blocks the ability
of 14-3-3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.
Induces apoptosis when expressed in COS-7 and various cancer cells.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Masters and Fu (2001) 14-3-3 proteins mediate an essential anti-apoptotic
signal. J.Biol.Chem. 276 45193. Masters et al
(2002) Survival-promoting functions of 14-3-3 proteins.
Biochem.Soc.Transactions 30 360. Hermeking (2003) The
14-3-3 cancer connection. Nature Rev.Cancer 3 931.
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View related products by Pharmacological Action
or by Research Area
Keywords: Difopein, Apoptosis, High Affinity Inhibitor Of 14-3-3 Proteins; Induces Apoptosis, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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