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Category:
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Transporters Neurotransmitter Transporters5-HT Transporters
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Cat.No.
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Product Name
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2695 |
Dexfenfluramine hydrochloride
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| Alternative name(s): |
(+)-Fenfluramine |
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Price and Availability
Click here for full price details of
Dexfenfluramine
Other Information:
DEA controlled substance.
Please consult your local
office for further information
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Chemical Name:
(S)-N-Ethyl-a-methyl-3-(trifluoromethyl)benzeneethanami
ne hydrochloride |
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Biological Activity:
Indirectly agonises serotonin receptors via
inhibition of 5-HT re-uptake and stimulation of 5-HT release. Anorectic agent;
decreases growth hormone, insulin, leptin, fat mass, lean mass and increases
ghrelin in diet-switched diet-induced obese mice.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Caccia et al
(1997) Neuropharmacological effects of low and high doses of repeated oral
dexfenfluramine in rats: a comparison with fluoxetine. Pharmacol.Biochem.Behav.
57 851. Higgins et al (2001) Influence of the 5-HT2C
receptor antagonist SB242,084 on behaviour produced by the 5-HT2
agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine.
Br.J.Pharmacol. 133 459. Bush et al (2006) Chronic
treatment with either dexfenfluramine or sibutramine in diet-switched diet-induced
obese mice. Endocrine 29 375.
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Keywords: Dexfenfluramine, Neurotransmitter Transporters, 5-HT Re-uptake Inhibitor. Also Stimulates 5-HT Release, (+)-Fenfluramine, Tocris Bioscience
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