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Category:
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7TM Receptors 5-HT Receptors5-HT2 Receptors5-HT2A
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Cat.No.
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Product Name
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2643 |
DOI hydrochloride
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Price and Availability
Click here for full price details of
DOI
Other Information:
This is a controlled substance with associated
conditions of supply; the relevent licence/documentation from the appropriate
governing body will be required.
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Chemical Name:
4-Iodo-2,5-dimethoxy-a-methylbenzeneethanamine
hydrochloride |
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Biological Activity:
Brain penetrant, mixed 5-HT2A/5-HT2C
receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A,
5-HT2C and 5-HT2B receptors respectively). Reduces rapid
eye movement (REM) and slow wave sleep and increases waking in the rat.
Hallucinogenic agent.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ichikawa and Meltzer (1995) DOI, a 5-HT2A/2C receptor agonist, potentiates
amphetamine-induced dopamine release in rat striatum. Brain Res. 698
204. Nelson et al (1999) Comparisons of hallucinogenic
phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B
and 5-HT2C receptors. Naunyn-Schmied.Arch.Pharmacol. 359
1. Monti and Jantos (2006) Effects of serotonin 5-HT2A/2C
receptor agonist DOI and of the selective 5-HT2A or 5-HT2C
receptor antagonists EMD 281014 and SB-243213 respectively, on sleep and waking
in the rat. Eur.J.Pharmacol. 553 163.
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Keywords: DOI, 5-HT Receptors, Mixed 5-HT2A / 2C Agonist, Tocris Bioscience
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