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Category:
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Ion Channels Potassium ChannelsOther Potasium Channels
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Biological Activity:
K+
channel blocker and acetylcholine release stimulator. Potently enhances K+-stimulated
[3H]-ACh release from rat hippocampal slices (EC50 = 700
nM), and also increases release of dopamine and glutamate (EC50
values are 0.25 and 0.22 μM, respectively). Orally active in
vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg)
and exerts a long duration of action. More potent than linopirdine (Cat. No.
1999) both in vitro and in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Zaczek et al
(1998) Two new potent neurotransmitter release enhancers,
10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and
10,10-Bis(2-flouro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to
linopirdine. J.Pharmacol.Exp.Ther. 285 724. Earl et al (1998)
2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active
acetylcholine release-enhancing agents with good efficacy and duration of
action. J.Med.Chem. 41 4615.
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View related products by Pharmacological Action
or by Research Area
Keywords: DMP 543, Potassium Channels, K+ Channel Blocker & Potent ACh Release Enhancer, DMP543, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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