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Category:
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Cellular Processes and Components Signal TransductionHsp90
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Cat.No.
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Product Name
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2610 |
17-DMAG hydrochloride
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| Alternative name(s): |
NSC 707545 |
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Price and Availability
Click here for full price details of
17-DMAG
Other Information:
Sold with
the permission of the NIH, US Patent 6,890,917
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Chemical Name:
17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanam
ycin hydrochloride |
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Biological Activity:
Water-soluble analogue of 17-AAG (Cat. No. 1515) and geldanamycin
(Cat. No. 1368). Binds the ATP binding site of Hsp90 and inhibits its chaperone
activity. Displays more potent antitumour activity than 17-AAG (mean GI50
values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Egorin et al (2002) Pharmacokinetics, tissue distribution, and
metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC
707545) in CD2F1 mice and fischer 344 rats. Cancer
Chemother.Pharmacol. 49 7. Smith et al (2005)
Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and
17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and
client proteins in melanoma models. Cancer Chemother.Pharmacol. 56
126. Dote et al (2006) Inhibition of Hsp90 compromises the DNA
damage response to radiation. Cancer Res. 66 9211.
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Keywords: 17-DMAG, Signal Transduction, Water-soluble Hsp90 Inhibitor, NSC 707545, 17DMAG, Tocris Bioscience
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