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Category:
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Enzymes Decarboxylases
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Cat.No.
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Product Name
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2761 |
DFMO
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| Alternative name(s): |
Eflornithine |
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Price and Availability
Click here for full price details of
DFMO
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Chemical Name:
DL-2-(Difluoromethyl)-ornithine hydrochloride |
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Biological Activity:
Inhibitor of ornithine decarboxylase that
inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and
antiparasitic activity.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Takahashi et al (2000)
α-Difluoromethylornithine induces
apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and
metastasis in a human gastric cancer model. Int.J.cancer 85 243. Carrillo
et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and
metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279
663. Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an
inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent.
Biochem.Soc.Trans. 35 353.
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or by Research Area
Keywords: DFMO, Decarboxylases, Ornithine Decarboxylase Inhibitor, Eflornithine, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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