Z-DEVD-FMK | Proteases | Cell-permeable, Irreversible Caspase-3 Inhibitor | ZDEVD-FMK

Category:

Cat.No.	Product Name
2166	Z-DEVD-FMK

Price and Availability

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Z-DEVD-FMK

Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoro methylketone

Biological Activity:

Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumour cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.

Technical Data:

M.Wt:	668.67
Formula:	C₃₀H₄₁FN₄O₁₂
Storage:	Store at -20°C
Solubility:	Soluble to 20 mM in DMSO

Resources:

Certificate of Analysis / MSDS:

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References:

Brocksted et al (1998) Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 273 28057. Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215. Kugawa et al (2000) Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 23 930.

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Keywords: Z-DEVD-FMK, Proteases, Cell-permeable, Irreversible Caspase-3 Inhibitor, ZDEVD-FMK, Tocris Bioscience

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