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Category: Ion ChannelsarrowLigand-gated Ion ChannelsarrowGlutamate (Ionotropic) ReceptorsarrowNon-Selective Ionotropic Glutamate
Cat.No. Product Name
1394 (RS)-3,4-DCPG
Price and Availability

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(RS)-3,4-DCPG
Chemical Name: (RS)-3,4-Dicarboxyphenylglycine

Biological Activity:

Systemically active anticonvulsant that is 30-100-fold more potent in vivo than the separate enantiomers (S)-3,4-DCPG (Cat. No. 1302; mGlu8-selective agonist) or (R)-3,4,-DCPG (Cat. No. 1395; AMPA/NMDA antagonist).

Technical Data:

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M.Wt: 239.18
Formula: C10H9NO6
Storage: Desiccate at RT
Solubility: Soluble to 50 mM in Water
Purity: >99%

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    References:

    Thomas et al (1997) Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur.J.Pharmacol. 338 111. Thomas et al (1998) Pharmacological differentiation of kainate receptors on neonatal rat spinal motoneurones and dorsal roots. Neuropharmacology 37 1223. Moldrich et al (2001) Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice. Neuropharmacology 40 732.
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    Keywords: (RS)-3,4-DCPG, Ligand-gated Ion Channels, AMPA / NMDA Antagonist / MGlu8 Agonist. Anticonvulsant, 3,4DCPG, Tocris Bioscience
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