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Category:
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Cellular Processes and Components ApoptosisApoptosis Inducer
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Cat.No.
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Product Name
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2137 |
2,3-DCPE hydrochloride
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Price and Availability
Click here for full price details of
2,3-DCPE
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Chemical Name:
2-[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol
hydrochloride |
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Biological Activity:
Selectively induces apoptosis and downregulates
Bcl-XL protein expression in various human cancer cells versus normal cells in
vitro. IC50 values are 0.89 and 12.6 μM for LoVo
human colon cancer cell line and normal human fibroblasts respectively. Induces
p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Wu et al (2004) Induction of apoptosis and down-regulation of
Bcl-XL in cancer cells by a novel small molecule,
2[[3-(2,3-Dichlorophenoxy)propyl]amino]ethanol. Cancer Res. 64
1110. Zhu et al (2004) Induction of S-phase arrest and p21
overexpression by a small molecule
2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol in correlation with activation
of ERK. Oncogene 23 4984.
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or by Research Area
Keywords: 2,3-DCPE, Apoptosis, Selectively Induces Cancer Cell Apoptosis, 2,3DCPE, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
| “I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..” Researcher, University of Pisa, Italy |
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