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Category:
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Enzymes ProteasesSecretase
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Cat.No.
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Product Name
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2634 |
DAPT
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Price and Availability
Click here for full price details of
DAPT
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Chemical Name:
N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycin
e-1,1-dimethylethyl ester |
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Biological Activity:
Inhibitor of γ-secretase;
causes a reduction in Aβ40 and Aβ42
levels in human primary neuronal cultures (IC50 values are 115 and
200 nM for total Aβ and Aβ42
respectively) and in brain extract, cerebrospinal fluid and plasma in vivo.
Does not effect APPα and APPβ
levels. Blocks notch signalling in hybrid human-mouse foetal thymus organ
culture (FTOC).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Dovey et
al (2001) Functional gamma-secretase inhibitors reduce beta-amyloid peptide
levels in brain. J.Neurochem. 76 173. De Smedt et al
(2005) Different thresholds of notch signaling bias human precursor cells
towards B-, NK-, monocytic/dendritic, or T-cell lineage in thymus
microenvironment. Blood 106 3498. El Mouedden et al
(2006) Reduction in Abeta levels in Sprague Dawley rat after oral
administration of the functional gamma-secretase inhibitor, DAPT: a novel
non-transgenic model for Abeta production inhibitors. Curr.Pharmaceut.Des. 12
671.
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View related products by Pharmacological Action
or by Research Area
Keywords: DAPT, Proteases, G-secretase Inhibitor, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
Product Feature
γ-Secretase Inhibitors
Key γ-secretase Inhibitors available from Tocris include:
2634
DAPT
Reduces Aβ40 & Aβ42 levels in human primary neuronal cultures
2677
JLK 6
Selectively inhibits βAPP cleavage
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