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Category: EnzymesarrowKinasesarrowCasein Kinase
Cat.No. Product Name
2902 D 4476
Price and Availability

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D 4476

Other Information:

Sold with the permission of GlaxoSmithKline
Chemical Name: 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl) -1H-imidazol-2-yl]benzamide

Biological Activity:

Selective inhibitor of casein kinase 1 (CK1) and TGF-β type-I receptor (ALK5) that displays > 20-fold selectivity over SAPK2/p38 and a much greater selectivity over all other protein kinases tested. Suppresses site-specific phosphorylation and nuclear exclusion of FOXO1a.

Technical Data:

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M.Wt: 398.41
Formula: C23H18N4O3
Storage: Store at +4°C
Solubility: Soluble to 100 mM in DMSO and to 50 mM in Ethanol
Purity: >99%
CAS No: [301836-43-1]

Resources:

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    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Callahan et al (2002) Identification of novel inhibitors of the transforming growth factor β1 (TGF-β1) type I receptor (ALK5). J.Med.Chem. 45 999. Rena et al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60. Bain et al (2007) The selectivity of protein kinase inhibitors: a further update. Biochem.J. 408 297.
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    Keywords: D 4476, Kinases, Selective CK1 Inhibitor. Also Inhibits TGF-b RI, D4476, Tocris Bioscience
    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
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    Product Feature
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