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Category:
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Cellular Processes and Components Cytoskeleton and Motor ProteinsMicrotubules
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Cat.No.
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Product Name
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1643 |
D-64131
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Price and Availability
Click here for full price details of
D-64131
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Chemical Name:
(5-Methoxy-1H-indol-2-yl)phenylmethanone |
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Biological Activity:
Novel
inhibitor of tubulin polymerisation; cytotoxic and inhibits tumour cell
proliferation in vitro (IC50 = 74 nM). Prevents growth of tumour
models in mice following oral administration in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Mahboobi et al (2001) Synthetic
2-aroylindole derivatives as a new class of potent tubulin-inhibitory,
antimitotic agents. J.Med.Chem. 44 4535. Beckers et al (2002)
2-aroylindoles, a novel class of potent, orally active small molecule tubulin
inhibitors. Cancer Res. 62 3113.
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Keywords: D-64131, Cytoskeleton & Motor Proteins, Inhibitor Of Tubulin Polymerisation. Antitumour In Vivo, D64131, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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