Cyclopiazonic Acid | Signal Transduction | Inhibitor Of SERCA ATPase | A-Cyclopiazonic Acid

Category:

Cellular Processes and Components

Signal Transduction

Calcium Signalling

Calcium ATPase Modulators

Cat.No.

Product Name

1235

Cyclopiazonic Acid

Alternative name(s):

a-Cyclopiazonic acid

Cyclopiazonic Acid C20H20N2O3 (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one

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Cyclopiazonic Acid

Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b-hexahydr o-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd] indol-9-one

Biological Activity:

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca²⁺-ATPase.

Technical Data:

M.Wt:	336.39
Formula:	C₂₀H₂₀N₂O₃
Storage:	Store at -20°C
Solubility:	Soluble to 5 mM in Ethanol and to 100 mM in DMSO
Purity:	>98%
CAS No:	[18172-33-3]

Resources:

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References:

Plenge-Tellechea et al (1997) On the inhibition mechanism of sarcoplasmic or endoplasmic reticulum Ca²⁺-ATPases by cyclopiazonic acid. J.Biol.Chem. 272 2794. Soler et al (1998) Cyclopiazonic acid effect on Ca²⁺-dependent conformational states of the sarcoplasmic reticulum ATPase. Implication for the enzyme turnover. Biochemistry 37 4266. Takemoto et al (1998) Comparison of contractions produced by carbachol, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle. Br.J.Pharmacol. 124 1449.

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Keywords: Cyclopiazonic Acid, Signal Transduction, Inhibitor Of SERCA ATPase, A-Cyclopiazonic Acid, Tocris Bioscience

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