Click here for full price details of
Cycloheximide
Chemical Name:4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxyethyl]-2,
6-piperidinedione
Biological Activity:
Selective inhibitor of eukaryotic
(over prokaryotic) protein synthesis, blocking tRNA binding and release from
ribosomes. Induces apoptosis in a variety of transformed and normal cell lines,
including T-cells. Competitively inhibits the PPIase hFKBP12 (Ki =
3.4 μM). Antifungal antibiotic.
Obrig et al (1971) The mechanism by which cycloheximide and
related glutarimide antibiotics inhibit peptide synthesis on reticulocyte
ribosomes. J.Biol.Chem. 246 174. Tanget al (1999)
Cycloheximide-induced T-cell death is mediated by a Fas-associated death
domain-dependent mechanism. J.Biol.Chem. 274 7245. Christneret al (1999) Synthesis and cytotoxic evaluation of cycloheximide
derivatives as potential inhibitors of FKBP12 with neuroregenerative
properties. J.Med.Chem. 42 3615.
“Tocris is to be congratulated for continuing to meet the current demand for a rapid and reliable source of high-quality compounds that are urgently needed as pharmacological tools by a growing international population of cannabinoid researchers..”
