Cyanopindolol Hemifumarate | 5-HT Receptors | 5-HT1A / 1B Antagonist. Also B-adrenergic Antagonist

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Cat.No.	Product Name
0993	Cyanopindolol hemifumarate

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Cyanopindolol hemifumarate

Chemical Name: 4-[3-[tert-Butylamino]-2-hydroxypropoxy]-1H-indole-2-ca rbonitrile hemifumarate

Biological Activity:

5-HT_1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist.

Technical Data:

M.Wt:	345.4
Formula:	C₁₆H₂₁N₃O₂.½C₄H₄O₄
Storage:	Store at RT
Solubility:	Soluble to 100 mM in DMSO
Purity:	>98%
CAS No:	[106469-57-2]

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Certificate of Analysis / MSDS:

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References:

Engel et al (1986) Identity of presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT_1B binding sites. Naunyn-Schmied.Arch.Pharmacol. 332 1. Blue et al (1989) Interaction of dihydroalprenolol and cyanopindolol with atypical β-adrenoceptors in guinea-pig ileum. Br.J.Pharmacol. 96 246P. Giles et al (1996) Characterization of a 5-HT_1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br.J.Pharmacol. 117 1119. Hoey et al (1996) Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol. Br.J.Pharmacol. 117 712.

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Keywords: Cyanopindolol Hemifumarate, 5-HT Receptors, 5-HT1A / 1B Antagonist. Also B-adrenergic Antagonist, Tocris Bioscience

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