Complement
inhibitor; binds C3 inhibiting proteolytic cleavage by C3 convertase (IC50
= 28 μM) and activation of classical and alternative complement
pathways (IC50 values are 63 and 12 μM respectively). Prolongs graft
survival and reduces hyperacute rejection of ex vivo pig kidneys perfused with
human blood and inhibits in vivo heparin/protamine-induced complement
activation in baboons.
Sahuet al (1996) Inhibition of
human complement by a C3-binding peptide isolated from a phage-displayed random
peptide library. J.Immunol. 157 884.Fianeet al (1999) Compstatin,
a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig
xenografts. Xenotransplantation 6 52. Soulikaet al
(2000) Inhibition of heparin/protamine complex-induced complement activation by
compstatin in baboons. Clin. Immunol. 96 212.
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