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Category: EnzymesarrowProteasesarrowSecretase
Cat.No. Product Name
2654 Compound W
Alternative name(s): CW
Price and Availability

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Compound W
Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid

Biological Activity:

Inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).

Technical Data:

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M.Wt: 396.31
Formula: C19H12N2O8
Storage: Store at +4°C
Solubility: Soluble to 50 mM in 1.1 eq. NaOH and to 100 mM in DMSO
Purity: >99%
CAS No: [173550-33-9]

Resources:

    		•

    • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch

    References:

    Okochi et al (2006) Secretion of the notch-1 Aβ-like peptide during notch signaling. J.Biol.Chem. 281 7890.
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    Keywords: Compound W, Proteases, G-secretase Inhibitor, CW, Tocris Bioscience
    Literature in this Area
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    Product Feature
    γ-Secretase Inhibitors
    Key γ-secretase Inhibitors available from Tocris include:
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    Reduces Aβ40 & Aβ42 levels in human primary neuronal cultures
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    Selectively inhibits βAPP cleavage
    2654   Compound W
    Decreases released levels of Aβ42 & Nβ25
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