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Category:
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Ion Channels Sodium ChannelsVoltage-gated Sodium Channels
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Cat.No.
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Product Name
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2642 |
Co 102862
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| Alternative name(s): |
V102862 |
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Price and Availability
Click here for full price details of
Co 102862
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Chemical Name:
2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarbox
amide |
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Biological Activity:
Broad spectrum, state-dependent blocker of
voltage-gated sodium channels. Displays ~ 80-fold higher affinity for
inactivated Na+ channels compared to channels in the resting state.
Anticonvulsant; displays activity in rodent models of tonic/clonic and
partial-complex seizures.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Ilyin et al (2005)
V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of
mammalian voltage-gated sodium channels. Br.J.Pharmacol. 144 801.
Ilyin et al (2006) Pharmacology of
2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent,
broad-spectrum state-dependent sodium channel blocker for treating pain states.
J.Pharmacol.Exp.Ther. 318 1083.
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or by Research Area
Keywords: Co 102862, Sodium Channels, State-dependent Na+ Channel Blocker; Anticonvulsant, V102862, Co102862, Tocris Bioscience
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