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Category: 7TM ReceptorsarrowAdrenergic ReceptorsarrowAlpha-2 ReceptorsarrowAgonists
Cat.No. Product Name
0690 Clonidine hydrochloride  
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Clonidine hydrochloride
Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride

Biological Activity:

Prototypical I1 imidazoline receptor ligand. α2-adrenergic receptor agonist. Antihypertensive.

Technical Data:

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M.Wt: 266.56
Formula: C9H9CI2N3.HCl
Storage: Store at RT
Solubility: Soluble to 10 mM in Water
Purity: >99%
CAS No: [4205-91-8]

Resources:

  • Certificate of Analysis / MSDS:

    Certificate of Analysis: View current batch
    Product/Material Safety Data Sheet: View current batch
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    References:

    Merck Index 12 2450. Ernsberger et al (1987) Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla. Eur.J.Pharmacol. 134 1. Greney et al (1994) Isolation of a human cerebral imidazoline-specific binding protein. Eur.J.Pharmacol. 265 R1.  Silva et al (1996) Dual effect of clonidine on mesenteric artery adrenoreceptors: agonistic (alpha-2) and antagonistic (alpha-1). J.Pharmacol.Exp.ther. 277 872. Armitsu et al (1998) Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle. J.Pharmacol.Exp.Ther. 286 681.
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    Keywords: Clonidine Hydrochloride, Adrenergic Receptors, A2 Agonist. Also I1 Ligand, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Adrenoceptor Pharmacology
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