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Category:
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Biotools Enzyme Substrates / Activators
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Cat.No.
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Product Name
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2600 |
Clofarabine
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Price and Availability
Click here for full price details of
Clofarabine
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Chemical Name:
2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-p
urin-6-amine |
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Biological Activity:
Deoxycytidine
kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which
competes with dATP for DNA polymerase-α and -e and potently inhibits ribonucleotide
reductase (IC50 = 65 nM). Induces apoptosis by directly altering
mitochondrial transmembrane potential. Demonstrates growth inhibition and
cytotoxic activity in a variety of leukaemias and solid tumours.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Parker et al (1991) Effects of
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine on K562 cellular
metabolism and the inhibition of human ribonucleotide reductase and DNA
polymerases by its 5'-triphosphate. Cancer Res. 51 2386. Carson
et al (1992) Oral antilymphocyte activity and induction of apoptosis by
2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Proc.Natl.Acad.Sci.USA 89
2970. Bonate et al (2006) Discovery and development of
clofarabine: a nucleoside analogue for treating cancer. Nat.Rev.Drug Discov. 5
855.
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Keywords: Clofarabine, Enzyme Substrates / Activators, Deoxycytidine Kinase (dCK) Substrate, Tocris Bioscience
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