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Category: 7TM ReceptorsarrowHistamine ReceptorsarrowH2 ReceptorsarrowAntagonists
Cat.No. Product Name
0902 Cimetidine  
Price and Availability

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Cimetidine
Chemical Name: N-Cyano-N'-methyl-N''-[2-[(5-methyl-1H-imidazol-4-yl)me thyl]thio]ethyl]guanidine

Biological Activity:

Widely used H2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I1 imidazoline binding site ligand.

Technical Data:

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M.Wt: 252.34
Formula: C10H16N6S
Storage: Store at RT
Solubility: Soluble to 50 mM in Water
Purity: >99%
CAS No: [51481-61-9]

Resources:

  • Certificate of Analysis / MSDS:

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    References:

    Hill (1990) Distribution, properties and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45. Ernsberger et al (1992) A second generation of centrally acting hypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1. Tsoli et al (1995) The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of langerhans. Eur.J.Pharmacol. 284 199. Smit et al (1996) Inverse agonism of histamine H2 antagonists accounts for upregulation of spontaneously active receptors. Proc.Natl.Acad.Sci.USA 93 6802.
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    Keywords: Cimetidine, Histamine Receptors, H2 Antagonist, I1 Agonist, Tocris Bioscience

    Literature in this Area
    Scientific Reviews
    Histamine Receptors
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    I am grateful for your honesty and courtesy. The principles of Tocris are very different to that of your competitors who, in fact, have put our inhibitor on the market without any approval, exhibiting a pirate policy and a total absence of ethics..”
    Researcher, University of Pisa, Italy
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