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Category:
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Ion Channels Calcium ChannelsVoltage-gated Calcium Channels
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Cat.No.
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Product Name
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2629 |
Cilnidipine
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| Alternative name(s): |
FRC 8653 |
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Price and Availability
Click here for full price details of
Cilnidipine
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Chemical Name:
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridine
dicarboxylic acid 2-methoxyethyl
(2E)-3-phenyl-2-propenyl ester |
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Biological Activity:
Dual
L- and N-type calcium channel antagonist that displays antihypertensive,
sympatholytic and neuroprotective activity. Lowers mean blood pressure and
reduces the size of cerebral infarction in the rat model of focal brain
ischaemia.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Murai et al (2000) Preferential
inhibition of L- and N-type calcium channels in the rat hippocampal neurons by
cilnidipine. Brain Res. 854 6. Nap et al (2004) The
evaluation of the N-type channel blocking properties of cilnidipine and other
voltage-dependent calcium antagonists. Fund.Clin.Pharmacol. 18
309. Takahara et al (2004) Neuroprotective effects of a dual
L/N-type Ca2+ channel blocker cilnidipine in the rat focal brain
ischemia model. Biol.Pharm.Bull. 27 1388.
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View related products by Pharmacological Action
or by Research Area
Keywords: Cilnidipine, Calcium Channels, Dual L / N-type Ca2+ Channel Antagonist, FRC 8653, Tocris Bioscience
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Literature in this Area Scientific Reviews
Mechanisms for Manipulating Intracellular Calcium Buffering Download PDF Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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