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Category: Ion ChannelsarrowPotassium ChannelsarrowVoltage-Gated Potassium Channels
Cat.No. Product Name
1475 (-)-[3R,4S]-Chromanol 293B
Price and Availability

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(-)-[3R,4S]-Chromanol 293B
Chemical Name: N-[(3R,4S)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2 H-1-benzopyran-4-yl]-N-methylethanesulfonamide

Biological Activity:

Enantiomer that selectively inhibits the slow component of delayed rectifier K+ current (IKs). Block is use-dependent and 7-fold more potent than the (+)-(3S,4R) enantiomer (IC50 values are 1.36 and 9.6 μM respectively). Has negligible inhibitory action at hERG channels (IC50 > 30 μM).

Technical Data:

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M.Wt: 324.39
Formula: C15H20N2O4S
Storage: Store at RT
Solubility: Soluble to 100 mM in Ethanol and to 100 mM in DMSO
Purity: >99%
CAS No: [163163-24-4]

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    References:

    Yang et al (2000) Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 294 955. Seebohm et al (2001) A kinetic study on the stereospecific inhibition of KCNQ1 and IKs by the chromanol 293B. Br.J.Pharmacol. 134 1647. Lerche et al (2001) Molecular impact of MinK on the enantiospecific block of IKs by chromanols. Br.J.Pharmacol. 131 1503.
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    Keywords: (-)-[3R,4S]-Chromanol 293B, Potassium Channels, IKs Blocker. Enantiomer Of (Cat. No. 1412), [3R4S]-Chromanol 293B, Tocris Bioscience
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