6-Chloromelatonin | Melatonin (MT) Receptors | Melatonin Agonist | 6Chloromelatonin

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Cat.No.	Product Name
0443	6-Chloromelatonin

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6-Chloromelatonin

Chemical Name: N-[2-(6-Chloro-5-methoxyindol-3-yl)ethyl]acetamide

Biological Activity:

Potent melatonin agonist (pK_i values are 9.10 and 9.77 for human recombinant MT₁ and MT₂ receptors respectively). Displays higher affinity for binding to hamster brain membrane and chicken retina than melatonin.

Technical Data:

M.Wt:	266.73
Formula:	C₁₃H₁₅ClN₂O₂
Storage:	Desiccate at +4°C
Solubility:	Soluble to 100 mM in DMSO
Purity:	>99%
CAS No:	[63762-74-3]

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References:

Dubocovich (1988) Luzindole (NO 774): A novel melatonin receptor antagonist. J.Pharmacol.Exp.Ther. 246 902. Duncan et al (1988) 2-[¹²⁵I]Iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinol. 122 1825. Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50. Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt₁ and MT₂ receptors. Br.J.Pharmacol. 129 877.

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Keywords: 6-Chloromelatonin, Melatonin (MT) Receptors, Melatonin Agonist, 6Chloromelatonin, Tocris Bioscience

Literature in this Area

Scientific Reviews

Melatonin Receptors
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