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Category: EnzymesarrowKinasesarrowProtein Kinase C
Cat.No. Product Name
1330 Chelerythrine chloride
Price and Availability

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Chelerythrine chloride
Chemical Name: 1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanth ridinium chloride

Biological Activity:

Potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumour effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis.

Technical Data:

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M.Wt: 383.83
Formula: C21H18ClNO4
Storage: Desiccate at -20°C
Solubility: Soluble to 10 mM in Water and to 25 mM in DMSO
Purity: >98%
CAS No: [34316-15-9]

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    References:

    Herbert et al (1990) Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Comm. 172 993. Lee et al (1998) Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem. 273 19829. Yu et al (2000) Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem. 275 9612. Chan et al (2003) Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 278 20453.
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    Keywords: Chelerythrine Chloride, Kinases, Potent Protein Kinase C Inhibitor, Tocris Bioscience
    Literature in this Area
    Signal Transduction Guide
    Signal Transduction Guide : An informative guide for all scientists working in: Cell cycle & apoptosis, Protein kinases & phosphatases, Ion channels, Calcium & lipid signaling, Cyclic nucleotides & G-proteins, Nitric oxide, & Signaling EnzymesA complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes.
    View PDF
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