Cetirizine | Histamine Receptors | Selective H1 Antagonist | P 071

Category:

7TM Receptors

Histamine Receptors

H1 Receptors

Antagonists

Cat.No.

Product Name

2577

Cetirizine dihydrochloride

Alternative name(s):

P 071

Cetirizine C21H25ClN2O3.2HCl [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

Price and Availability

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Cetirizine

Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]etho xy]acetic acid dihydrochloride

Biological Activity:

Histamine H₁ receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.

Technical Data:

M.Wt:	461.81
Formula:	C₂₁H₂₅ClN₂O₃.2HCl
Storage:	Desiccate at RT
Solubility:	Soluble to 100 mM in Water and to 100 mM in DMSO
Purity:	>99%
CAS No:	[83881-52-1]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Campoli-Richards et al (1990) Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 40 762. Snowman and Snyder (1990) Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 86 1025. Walsh et al (1991) Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 95 158.

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Keywords: Cetirizine, Histamine Receptors, Selective H1 Antagonist, P 071, Tocris Bioscience

Literature in this Area

Scientific Reviews

Histamine Receptors
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