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Category:
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Cellular Processes and Components ApoptosisApoptosis Inducer
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Cat.No.
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Product Name
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2626 |
Carboplatin
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| Alternative name(s): |
NSC
241240 |
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Paraplatin |
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JM
8 |
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Price and Availability
Click here for full price details of
Carboplatin
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Chemical Name:
cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) |
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Biological Activity:
Antitumour
agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA
crosslinks blocking DNA replication and transcription. Enhances
radiation-induced single-strand DNA breakage and displays lower nephrotoxicity
than analogue cisplatin (Cat. No. 2251).
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
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References:
Yang et al (1995) Carboplatin
enhances the production and persistence of radiation-induced DNA single-strand
breaks. Radiation Res. 143 302. Natarajan et al
(1999) Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum
(II) (carboplatin) in the presence of nucleophiles and human breast cancer
MCF-7 cell cytoplasmic extracts: activation theory revisited.
Biochem.Pharmacol. 58 1625. Thomas et al (2006)
High accumulation of platinum-DNA adducts in strial marginal cells of the
cochlea is an early event in cisplatin but not carboplatin ototoxicity.
Mol.Pharmacol. 70 23.
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View related products by Pharmacological Action
or by Research Area
Keywords: Carboplatin, Apoptosis, DNA Cross-linking Antitumour Agent, NSC 241240, Paraplatin, JM 8, Tocris Bioscience
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Literature in this Area Signal Transduction Guide | A complete listing of signal transduction products available from Tocris, including descriptions on selected tools and unit sizes. | | View PDF |
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