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Category: Ion ChannelsarrowTransient Receptor Potential ChannelsarrowTRPV
Cat.No. Product Name
0464 Capsazepine  
Price and Availability

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Capsazepine
Chemical Name: N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihy droxy-2H-2-benzazepine-2-carbothioamide

Biological Activity:

Selective vanilloid receptor antagonist (Ki = 3.2 μM). Inhibits carrageenan inflammation-induced hyperalgesic responses in the rat. Also activates amiloride-sensitive epithelial Na+ channel ENaCδ.

Technical Data:

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M.Wt: 376.9
Formula: C19H21ClN2O2S
Storage: Store at RT
Solubility: Soluble to 25 mM in Ethanol and to 100 mM in DMSO
Purity: >99%
CAS No: [138977-28-3]

Resources:

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    References:

    Dickenson and Dray (1991) Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception. Br.J.Pharmacol. 104 1045. Kwak et al (1998) A capsaicin-receptor antagonist, capsazepine, reduces inflammation-induced hyperalgesic responses in the rat: evidence for an endogenous capsaicin-like substance. Neuroscience 86 619. Yamamura et al (2004) Capsazepine is a novel activator of the δ subunit of the human epithelial Na+ channel. J.Biol.Chem. 279 44483.
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    Keywords: Capsazepine, Transient Receptor Potential Channels, Vanilloid Receptor Antagonist. Also Activator Of ENaCd, Tocris Bioscience
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