Calmidazolium Chloride | Signal Transduction | Calmodulin Antagonist | R 24571

Category:

Cellular Processes and Components

Signal Transduction

Calcium Signalling

Calcium Binding Protein Modulators

Cat.No.

Product Name

2561

Calmidazolium chloride

Alternative name(s):

R 24571

Calmidazolium chloride C31H23Cl7N2O 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride

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Calmidazolium chloride

Chemical Name: 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl) -2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride

Biological Activity:

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca²⁺-transporting ATPase with IC₅₀ values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

Technical Data:

M.Wt:	687.7
Formula:	C₃₁H₂₃Cl₇N₂O
Storage:	Store at +4°C
Solubility:	Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Purity:	>99%
CAS No:	[57265-65-3]

Resources:

Certificate of Analysis / MSDS:

Certificate of Analysis: View current batch

Product/Material Safety Data Sheet: View current batch

References:

Gietzen (1983) Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem.J. 216 611. Harper and Daly (2000) Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochem.Pharmacol. 60 317. Peppiatt et al (2004) Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem.J. 381 929.

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Keywords: Calmidazolium Chloride, Signal Transduction, Calmodulin Antagonist, R 24571, Tocris Bioscience

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